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Nervousness, abnormal heartbeat, muscle pain, weakness, leg cramps, and water retention occur infrequently. Proton pump inhibitors may increase the risk of Clostridium difficile infection.

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High doses and long-term use 1 year or longer may increase the risk of osteoporosis -related fractures of the hip, wrist, or spine. Prolonged use also reduces absorption of vitamin B12 cyanocobalamin. Long-term use of PPIs has also been associated with low levels of magnesium hypomagnesemia. Analysis of patients taking PPIs for long periods of time showed an increased risk of heart attacks, Generic Esomeprazole No Prescription.

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Therefore, it is important to use the lowest doses and shortest duration of treatment necessary for the condition being treated. Common Misconceptions See Slideshow What is the dosage for esomeprazole?

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For GERD, 20 or 40 mg of esomeprazole is given once daily for 4-8 weeks. In children ages 1-11, the dose is 10 or 20 mg daily. For the treatment of H. Frequent heartburn is treated with 20 mg daily for 14 days.

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Zollinger-Ellison syndrome is treated with 40 mg twice daily. Patients with difficulty swallowing can open the capsule Esomeprazole mix the pellets with applesauce. Esomeprazole potentially can increase the prescription in blood of diazepam Valium, Diastat by generic the elimination of diazepam in the liver.

Therefore, esomeprazole and other PPIs that reduce stomach acid also reduce the absorption and concentration in blood of ketoconazole Nizoral and increase the absorption and concentration in blood of digoxin Lanoxin. This may lead to reduced effectiveness of ketoconazole or increased digoxin toxicity, Generic Esomeprazole No Prescription, respectively.

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Clopidogrel Plavix is converted to its active form by enzymes in the liver. Esomeprazole reduces the activity of these enzymes and potentially can reduce the activity of clopidogrel.

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Esomeprazole should not be used with clopidogrel. Esomeprazole increases the concentration of cilostazol Pletal and its metabolites. The dose of cilostazol should be reduced from 100 mg twice daily to 50 mg twice daily when given with esomeprazole. Esomeprazole may increase blood levels of methotrexate Rheumatrex, Trexall and tacrolimus Prograf.

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