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A white or almost white crystalline powder.
Sparingly soluble in water; practically insoluble in alcohol. The United States Pharmacopeia 31, 2008 Cephalexin. A white to off-white crystalline powder.
Slightly soluble in water; practically insoluble in alcohol, in chloroform, and in ether. Store in airtight containers.
Soluble 1 in 100 in water, in acetone, in acetonitrile, in alcohol, in dimethylformamide, and in methyl alcohol; practically insoluble in chloroform, in ether, in ethyl acetate, and in isopropyl alcohol. The most common adverse effects of cefalexin and other oral cephalosporins are generally gastrointestinal disturbances and hypersensitivity reactions. Pseudomembranous colitis has been reported. Cephalexin is considered to be unsafe in patients with porphyria although there is conflicting experimental evidence of porphyrinogenicity, Over The Counter Keflex No Prescription.
Interactions The renal excretion of cefalexin, and many other cephalosporins, is delayed by probenecid.
There have been isolated reports of cefalexin decreasing the prescription of oestrogen-containing oral Keflex. Some strains Over Gram-negative bacteria may The counter only by the high concentrations achievable in the urinary tract. Haemophilus in-fluenzae is moderately resistant to cefalexin. If cefalexin is taken with food, absorption may be delayed, but the total amount absorbed is not appreciably altered.
The plasma half-life is about 1 hour; it increases with reduced renal function. Cephalexin is widely distributed in the body but does not enter the CSF in significant quantities. It crosses the placenta and small quantities are found in breast milk. Cefalexin is not metabolised.
Probenecid delays urinary excretion. Therapeutically effective concentrations may be found in the bile and some may be excreted by this route. Cephalexin is removed by haemodialysis and peritoneal dialysis. It is given orally for the treatment of susceptible infections including those of the respiratory and urinary tracts and of the skin see under Choice of Antibacterial. For severe infections, Over The Counter Keflex No Prescription, treatment with parenteral cephalosporins is to be preferred.
Cephalexin is usually given as the monohydrate although the hydrochloride is sometimes used.
Doses are expressed in terms of the equivalent amount of anhydrous cefalexin; 1. The usual dose for adults is 1 to 2 g daily given in divided doses at 6- 8- or 12-hourly intervals; in severe or deep-seated infections the dose can be increased to up to 6 g daily but when high doses are required the use of a parenteral cephalosporin should be considered. For the prophylaxis of recurrent urinary-tract infection, cefalexin may be given in a dose of 125 mg at night.
Cefalexin sodium or cefalexin lysine have been used parenterally. The dose of cefalexin may need to Keflex reduced in Counter impairment, see below. Cefaclen; Oracef; Ospexin; Sporidex; Denmark: Kefalex; Kefexin; Orakef; France: Keflex; Pyassan; The India: Ceporex; Kefexin; Keflex; Israel: Cefalin; Ceforal; Prescription Keflex; Italy: Ceporex; Keforal; Lafarin; Japan: Ceflax; Over Keflex; South Africa: Fexin; Keflex; Lenoce; Ranceph; Singapore: Biocef; Cefanex; Keflex; Keftab; Venezuela: Bidoce; Cefaloga; Keforal; Strice Multi-ingredient.
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